Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Exposing synonymous mutations.

Trends in genetics : TIG - 1 Jul 2014

Hunt Ryan C, Simhadri Vijaya L, Iandoli Matthew, Sauna Zuben E, Kimchi-Sarfaty Chava

Abstract excerpt

Synonymous codon changes, which do not alter protein sequence, were previously thought to have no functional consequence. Although this concept has been overturned in recent years, there is no unique mechanism by which these changes exert biological effects. A large repertoire of both experimental and bioinformatic methods has been developed to understand the effects of synonymous variants. Results from this body...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Codon
Share to Nucleic Acid Conformation
Share to Protein Aggregation, Pathological

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Protein Biosynthesis

Share to Protein Stability

Share to Protein Unfolding

Share to RNA Splicing

Share to RNA Stability

Source

Identifiers

PMID: 24954581
DOI: 10.1016/j.tig.2014.04.006

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Exposing synonymous mutations.PMID 24954581Read ↗

Understanding the contribution of synonymous mutations to human disease.Semantic proximity Read ↗

A minimal role for synonymous variation in human diseaseSemantic proximity Read ↗

Decoding mechanisms by which silent codon changes influence protein biogenesis and function.Semantic proximity Read ↗

Code inside the codon: The role of synonymous mutations in regulating splicing machinery and its impact on disease.Semantic proximity Read ↗

When a Synonymous Variant Is Nonsynonymous.Semantic proximity Read ↗

Silent (synonymous) SNPs: should we care about them?Semantic proximity Read ↗

A minimal role for synonymous variation in human disease.Semantic proximity Read ↗

Roles for Synonymous Codon Usage in Protein Biogenesis.Semantic proximity Read ↗

Synonymous Variants: Necessary Nuance in Our Understanding of Cancer Drivers and Treatment Outcomes.Semantic proximity Read ↗

In silico methods for predicting functional synonymous variants.Semantic proximity Read ↗

Synonymous SNP: Rare versus frequent codon can cause Phenotypic changes in the human genomeSemantic proximity Read ↗

Silent mutations in sight: co-variations in tRNA abundance as a key to unravel consequences of silent mutations.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.