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Three fingers on the switch

7 Mar 2013

Abstract excerpt

PURPOSE OF REVIEW: Krüppel-like factor 1 (KLF1) regulates most aspects of erythropoiesis. Many years ago, transgenic mouse studies implicated KLF1 in the control of the human γ-globin to β-globin switch. In this review, we will integrate these initial studies with recent developments in human genetics to discuss our present understanding of how KLF1 and its target genes direct the switch. RECENT FINDINGS: Recent...

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PMID: 23474875
DOI: 10.1097/moh.0b013e32835f59ba

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