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Article

Novel single-cell technologies in acute myeloid leukemia research.

Translational research : the journal of laboratory and clinical medicine - 1 Nov 2017

Gupta Soumyasri Das, Sachs Zohar

Abstract excerpt

Acute myeloid leukemia (AML) is a lethal malignancy because patients who initially respond to chemotherapy eventually relapse with treatment refractory disease. Relapse is caused by leukemia stem cells (LSCs) that reestablish the disease through self-renewal. Self-renewal is the ability of a stem cell to produce copies of itself and give rise to progeny cells. Therefore, therapeutic strategies eradicating LSCs...

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Identifiers

PMID: 28802867
DOI: 10.1016/j.trsl.2017.07.007
PMCID: PMC6584944

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