Article
Function and regulation of ABCA1--membrane meso-domain organization and reorganization.
The FEBS journal - 1 Sept 2011
Nagao Kohjiro, Tomioka Maiko, Ueda Kazumitsu
Abstract excerpt
The ATP-binding cassette protein A1 (ABCA1) mediates the secretion of cellular-free cholesterol and phospholipids to an extracellular acceptor, apolipoprotein A-I, to form high-density lipoprotein. Because ABCA1 is a key factor in cholesterol homeostasis, elaborate transcriptional and post-transcriptional regulations of ABCA1 have evolved to maintain cholesterol homeostasis. Recent studies suggest that ABCA1...
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