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Article

The Role of Sirtuin-1 (SIRT1) in the Physiology and Pathophysiology of the Human Placenta

11 Nov 2023

Abstract excerpt

Sirtuins, especially SIRT1, play a significant role in regulating inflammatory response, autophagy, and cell response to oxidative stress. Since their discovery, sirtuins have been regarded as anti-ageing and longevity-promoting enzymes. Sirtuin-regulated processes seem to participate in the most prevalent placental pathologies, such as pre-eclampsia. Furthermore, more and more research studies indicate that...

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PMID: 38003402
DOI: 10.3390/ijms242216210

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