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Diverse actions of sirtuin-1 on ovulatory genes and cell death pathways in human granulosa cells

15 Jul 2022

Abstract excerpt

BACKGROUND: Human granulosa-lutein cells (hGLCs) amply express sirtuin-1 (SIRT1), a NAD + -dependent deacetylase that is associated with various cellular functions. SIRT1 was shown to elevate cAMP on its own and additively with human chorionic gonadotropin (hCG), it is therefore interesting to examine if SIRT1 affects other essential hGLC functions. METHODS: Primary hGLCs, obtained from the follicular aspirates...

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PMID: 35840944
DOI: 10.1186/s12958-022-00970-x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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