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Article

Microbiota-derived genotoxin tilimycin generates colonic stem cell mutations.

Cell reports - 28 Mar 2023

Pöltl Lisa, Kitsera Maksym, Raffl Sandra, Schild Stefan, Cosic Amar, Kienesberger Sabine, Unterhauser Katrin, Raber Georg, Lembacher-Fadum Christian, Breinbauer Rolf, Gorkiewicz Gregor, Sebastian Carlos, Hoefler Gerald, Zechner Ellen L

Abstract excerpt

The DNA-alkylating metabolite tilimycin is a microbial genotoxin. Intestinal accumulation of tilimycin in individuals carrying til+ Klebsiella spp. causes apoptotic erosion of the epithelium and colitis. Renewal of the intestinal lining and response to injury requires the activities of stem cells located at the base of intestinal crypts. This study interrogates the consequences of tilimycin-induced DNA damage to...

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Identifiers

PMID: 36870054
DOI: 10.1016/j.celrep.2023.112199

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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