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<i>Enterococcus faecalis</i> Induces Aneuploidy and Tetraploidy in Colonic Epithelial Cells through a Bystander Effect

1 Dec 2008

Abstract excerpt

Intestinal commensals are potential important contributors to the etiology of sporadic colorectal cancer, but mechanisms by which bacteria can initiate tumors remain uncertain. Herein, we describe mechanisms that link Enterococcus faecalis, a bacterium known to produce extracellular superoxide, to the acute induction of chromosomal instability. Immortalized human and nontransformed murine colonic epithelial...

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PMID: 19047172
DOI: 10.1158/0008-5472.can-08-1551

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