Article
Adaptation to Overflow Metabolism by Mutations That Impair tRNA Modification in Experimentally Evolved Bacteria.
mBio - 25 Apr 2023
Muraski Marc J, Nilsson Emil M, Fritz Melissa J, Richardson Anthony R, Alexander Rebecca W, Cooper Vaughn S
Abstract excerpt
When microbes grow in foreign nutritional environments, selection may enrich mutations in unexpected pathways connecting growth and homeostasis. An evolution experiment designed to identify beneficial mutations in Burkholderia cenocepacia captured six independent nonsynonymous substitutions in the essential gene tilS, which modifies tRNAIle2 by adding a lysine to the anticodon for faithful AUA recognition....
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