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Comprehensive Analysis of HIV-1 Integrase Resistance-Related Mutations in African Countries

24 Jan 2024

Abstract excerpt

The growing emergence of non-nucleoside reverse transcriptase inhibitor (NNRTI) HIV drug resistance in sub-Saharan Africa (SSA) led to the World Health Organization (WHO) recommending, in 2018, a transition to dolutegravir (DTG) as a first-line antiretroviral therapy (ART) in SSA. The broad HIV-1 genetic diversity in SSA could shape DTG effectiveness and the pattern of drug resistance mutations (DRMs) in this...

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PMID: 38392840
DOI: 10.3390/pathogens13020102

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