Article
Analyses of HIV-1 integrase sequences prior to South African national HIV-treatment program and available of integrase inhibitors in Cape Town, South Africa.
Scientific reports - 16 Mar 2018
Brado Dominik, Obasa Adetayo Emmanuel, Ikomey George Mondinde, Cloete Ruben, Singh Kamalendra, Engelbrecht Susan, Neogi Ujjwal, Jacobs Graeme Brendon
Abstract excerpt
HIV-Integrase (IN) has proven to be a viable target for highly specific HIV-1 therapy. We aimed to characterize the HIV-1 IN gene in a South African context and identify resistance-associated mutations (RAMs) against available first and second generation Integrase strand-transfer inhibitors (InSTIs). We performed genetic analyses on 91 treatment-naïve HIV-1 infected patients, as well as 314 treatment-naive South...
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