Article
HIV-2 integrase variation in integrase inhibitor-naïve adults in Senegal, West Africa.
PloS one - 1 Jan 2011
Gottlieb Geoffrey S, Smith Robert A, Dia Badiane Ndeye Mery, Ba Selly, Hawes Stephen E, Toure Macoumba, Starling Alison K, Traore Fatou, Sall Fatima, Cherne Stephen L, Stern Joshua, Wong Kim G, Lu Paul, Kim Moon, Raugi Dana N, Lam Airin, Mullins James I, Kiviat Nancy B
Abstract excerpt
BACKGROUND: Antiretroviral therapy for HIV-2 infection is hampered by intrinsic resistance to many of the drugs used to treat HIV-1. Limited studies suggest that the integrase inhibitors (INIs) raltegravir and elvitegravir have potent activity against HIV-2 in culture and in infected patients. There is a paucity of data on genotypic variation in HIV-2 integrase that might confer intrinsic or transmitted INI...
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