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Article

Variation in Mutational Robustness between Different Proteins and the Predictability of Fitness Effects.

Molecular biology and evolution - 1 Feb 2017

Lind Peter A, Arvidsson Lars, Berg Otto G, Andersson Dan I

Abstract excerpt

Random mutations in genes from disparate protein classes may have different distributions of fitness effects (DFEs) depending on different structural, functional, and evolutionary constraints. We measured the fitness effects of 156 single mutations in the genes encoding AraC (transcription factor), AraD (enzyme), and AraE (transporter) used for bacterial growth on l-arabinose. Despite their different molecular...

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Identifiers

PMID: 28025272
DOI: 10.1093/molbev/msw239

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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