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Article

Grouper cGAS is a negative regulator of STING-mediated interferon response

7 Feb 2023

Abstract excerpt

Cyclic GMP-AMP synthase (cGAS) is one of the classical pattern recognition receptors that recognizes mainly intracytoplasmic DNA. cGAS induces type I IFN responses to the cGAS-STING signaling pathway. To investigate the roles of cGAS-STING signaling pathway in grouper, a cGAS homolog (named EccGAS) was cloned and identified from orange-spotted grouper (Epinephelus coioides). The open reading frame (ORF) of EccGAS...

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PMID: 36845102
DOI: 10.3389/fimmu.2023.1092824

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