Article
Nucleotide modifications in messenger RNA and their role in development and disease.
Biochemical Society transactions - 15 Oct 2016
Dezi Veronica, Ivanov Chavdar, Haussmann Irmgard U, Soller Matthias
Abstract excerpt
Modified nucleotides in messenger RNA (mRNA) have been discovered over 40 years ago, but until recently little was known about which transcripts contain them and what their function is. High-throughput sequencing approaches revealed a dynamic landscape of the 'Epitranscriptome' for many mRNA modifications in various organisms from yeast to humans. Meanwhile, also many genes encoding mRNA-modifying enzymes and...
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