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Regulation of autophagy and EMT by the interplay between p53 and RAS during cancer progression (Review)

31 May 2017

Abstract excerpt

Cellular autophagy and epithelial-mesenchymal transition (EMT) are key events mostly resulted from the interplay of tumor suppressors and oncogenes during cancer progression. The master tumor suppressor p53 may control tumor cell autophagy and EMT through the transcriptional induction of multiple target genes, while the activated oncogene RAS may also play a critical role in regulating mitogenic signaling to...

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Identifiers

PMID: 28560457
DOI: 10.3892/ijo.2017.4025

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