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Article

The relevance of iron in the pathogenesis of Parkinson’s disease

7 Dec 2010

Abstract excerpt

Alterations of iron levels in the brain has been observed and documented in a number of neurodegenerative disorders including Parkinson's disease (PD). The elevated nigral iron levels observed in PD may reflect a dysfunction of brain iron homeostasis. Under normal physiological conditions excess iron can be sequestrated in ferritin and neuromelanin. Alternatively, the excess iron may represent a component of...

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PMID: 21138437
DOI: 10.1111/j.1471-4159.2010.07132.x

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