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Article

Interrelationship between microsatellite instability and microRNA in gastrointestinal cancer.

World journal of gastroenterology - 14 Jun 2012

Yamamoto Hiroyuki, Adachi Yasushi, Taniguchi Hiroaki, Kunimoto Hiroaki, Nosho Katsuhiko, Suzuki Hiromu, Shinomura Yasuhisa

Abstract excerpt

There is an increasing understanding of the roles that microsatellite instability (MSI) plays in Lynch syndrome (by mutations) and sporadic (by mainly epigenetic changes) gastrointestinal (GI) and other cancers. Deficient DNA mismatch repair (MMR) results in the strong mutator phenotype known as MSI, which is the hallmark of cancers arising within Lynch syndrome. MSI is characterized by length alterations within...

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Topics

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Share to Colorectal Neoplasms, Hereditary Nonpolyposis
Share to DNA Mismatch Repair

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epigenesis, Genetic

Share to Gene Expression Regulation, Neoplastic

Share to Genetic Predisposition to Disease

Share to MicroRNAs

Share to Microsatellite Instability

Share to Transcription, Genetic

Source

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Identifiers

PMID: 22719182
DOI: 10.3748/wjg.v18.i22.2745
PMCID: PMC3374977

Genes

MLH1
MSH2
MSH6
HDAC2
PMS2
TARBP2
XPO5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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