Article
Lack of evidence that fibrillin1 regulates bone morphogenetic protein 4 activity in kidney or lung.
Developmental dynamics : an official publication of the American Association of Anatomists - 1 Jun 2023
McKnite Autumn, Kim Hyung-Seok, Silva Joshua, Christian Jan L
Abstract excerpt
BACKGROUND: The Bone morphogenetic protein 4 (BMP4) precursor protein is cleaved at two sites to generate an active ligand and inactive prodomain. The ligand and prodomain form a noncovalent complex following the first cleavage, but dissociate after the second cleavage. Transient formation of this complex is essential to generate a stable ligand. Fibrillins (FBNs) bind to the prodomains of BMPs, and can regulate...
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