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Article

BMP1 is not required for lung fibrosis in mice

31 Mar 2022

Abstract excerpt

Bone morphogenetic protein 1 (BMP1) belongs to the astacin/BMP1/tolloid-like family of zinc metalloproteinases, which play a fundamental role in the development and formation of extracellular matrix (ECM). BMP1 mediates the cleavage of carboxyl terminal (C-term) propeptides from procollagens, a crucial step in fibrillar collagen fiber formation. Blocking BMP1 by small molecule or antibody inhibitors has been...

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PMID: 35361882
DOI: 10.1038/s41598-022-09557-3

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