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Article

BMP4 is dispensable for skeletogenesis and fracture-healing in the limb.

The Journal of bone and joint surgery. American volume - 1 Feb 2008

Tsuji Kunikazu, Cox Karen, Bandyopadhyay Amitabha, Harfe Brian D, Tabin Clifford J, Rosen Vicki

Abstract excerpt

Bone morphogenetic proteins (BMPs) are potent bone-forming agents that show clinical efficacy when used in patients to augment fracture-healing. Molecular profiling of fracture tissues has confirmed that BMPs 2, 3, 4, 5, 6, and 7 are expressed during the healing process, and it has identified a specific temporal pattern of expression for each BMP. Mice engineered to express increased levels of BMP antagonists...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 18292351
DOI: 10.2106/JBJS.G.01109

Genes

BMP4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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BMP2 activity, although dispensable for bone formation, is required for the initiation of fracture healingSemantic proximity Read ↗

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