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Article

Identifying gene targets for brain-related traits using transcriptomic and methylomic data from blood.

Nature communications - 11 Jun 2018

Qi Ting, Wu Yang, Zeng Jian, Zhang Futao, Xue Angli, Jiang Longda, Zhu Zhihong, Kemper Kathryn, Yengo Loic, Zheng Zhili, Marioni Riccardo E, Montgomery Grant W, Deary Ian J, Wray Naomi R, Visscher Peter M, McRae Allan F, Yang Jian

Abstract excerpt

Understanding the difference in genetic regulation of gene expression between brain and blood is important for discovering genes for brain-related traits and disorders. Here, we estimate the correlation of genetic effects at the top-associated cis-expression or -DNA methylation (DNAm) quantitative trait loci (cis-eQTLs or cis-mQTLs) between brain and blood (r b ). Using publicly available data, we find that...

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Identifiers

PMID: 29891976
DOI: 10.1038/s41467-018-04558-1
PMCID: PMC5995828

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Source receipt: pubmed, retrieved 7 Sept 2026.

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