Article
A phenomics-based strategy identifies loci on APOC1, BRAP, and PLCG1 associated with metabolic syndrome phenotype domains.
PLoS genetics - 1 Oct 2011
Avery Christy L, He Qianchuan, North Kari E, Ambite Jose L, Boerwinkle Eric, Fornage Myriam, Hindorff Lucia A, Kooperberg Charles, Meigs James B, Pankow James S, Pendergrass Sarah A, Psaty Bruce M, Ritchie Marylyn D, Rotter Jerome I, Taylor Kent D, Wilkens Lynne R, Heiss Gerardo, Lin Dan Yu
Abstract excerpt
Despite evidence of the clustering of metabolic syndrome components, current approaches for identifying unifying genetic mechanisms typically evaluate clinical categories that do not provide adequate etiological information. Here, we used data from 19,486 European American and 6,287 African American Candidate Gene Association Resource Consortium participants to identify loci associated with the clustering of...
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