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Schizophrenia and bipolar disorder: a comparative analysis of genetic and brain network connectivity.

Psychological medicine - 19 Jun 2026

Ren Hongyan, Liu Yunjia, Huang Yunqi, Tang Yiguo, Xiao Liling, Wu Yulu, Liu Siyi, Yin Yubing, Ma Qianshu, Dai Minhan, Tao Shiwan, Xie Min, Li Mingli, Li Tao, Wang Qiang

Abstract excerpt

BACKGROUND: Schizophrenia (SCZ) and bipolar disorder (BD) are severe psychiatric conditions with overlapping clinical presentations, genetic risk factors, and brain network dysfunction. Whether alterations in large-scale intrinsic brain networks reflect shared or disorder-specific genetic influences remains poorly understood. Clarifying this distinction is essential for refining etiological models and improving...

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PMID: 42317101
DOI: 10.1017/S0033291726104413
PMCID: PMC13280692

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