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Article

TP53 lacks tetramerization and N-terminal domains due to novel inactivating mutations detected in leukemia patients.

Journal of cancer research and therapeutics - 1 Jan 2000

Hameed Yasir, Ejaz Samina

Abstract excerpt

BACKGROUND: TP53 is a highly conserved tumor suppressor gene present on chromosome 17 and comprised 11 exons and 12 introns. The TP53 protein maintained the genomic integrity of the cell by regulating different pathways. The association of TP53 with leukemia and the increasing prevalence of leukemia in Pakistan instigated us to initiate the current study. MATERIALS AND METHODS: The TP53 gene of acute myeloid...

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Identifiers

PMID: 34528544
DOI: 10.4103/jcrt.JCRT_536_19

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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