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Article

Adh1 and Adh1/4 knockout mice as possible rodent models for presymptomatic Parkinson's disease.

Behavioural brain research - 1 Feb 2012

Anvret Anna, Ran Caroline, Westerlund Marie, Gellhaar Sandra, Lindqvist Eva, Pernold Karin, Lundströmer Karin, Duester Gregg, Felder Michael R, Galter Dagmar, Belin Andrea Carmine

Abstract excerpt

Alcohol dehydrogenases (ADH) catalyze the reversible metabolism of many types of alcohols and aldehydes to prevent the possible toxic accumulation of these compounds. ADHs are of interest in Parkinson's disease (PD) since these compounds can be harmful to dopamine (DA) neurons. Genetic variants in ADH1C and ADH4 have been found to associate with PD and lack of Adh4 gene activity in a mouse model has recently been...

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Source

Identifiers

PMID: 22079585
DOI: 10.1016/j.bbr.2011.10.040

Genes

ADH4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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