Article
Involvement of dimethylarginine dimethylaminohydrolase type 1 (DDAH1) in addiction and social stress phenotypes: Insights from proteomic, metabolomic and functional studies.
Progress in neuro-psychopharmacology & biological psychiatry - 20 Dec 2025
Nenov Miroslav N, Briand Lisa A
Abstract excerpt
Nitric oxide synthase (NOS) plays a role in substance use related neurotoxicity and addictive phenotypes. Inhibition of nitric oxide (NO) production can prevent negative phenotypes associated with drugs intake. Asymmetric dimethylarginine (ADMA) is an endogenous inhibitor of NOS. ADMA levels are regulated by dimethylarginine dimethylaminohydrolase type 1 (DDAH1). Numerous evidence suggests that drugs of abuse can...
Topics
- Amidohydrolases
- Humans
- Animals
- Stress, Psychological
- Proteomics
- Substance-Related Disorders
- Metabolomics
- Phenotype
- Brain
- Arginine
- Behavior, Addictive