Article
Warfarin-Rifampin-Gene (WARIF-G) Interaction: A Retrospective, Genetic, Case-Control Study.
Clinical pharmacology and therapeutics - 1 May 2023
Salem Muhammad, El-Bardissy Ahmed, Elshafei Mohamed Nabil, Khalil Ahmed, Mahmoud Hesham, Fahmi Amr Mohamed, Kasem Mohamed, Bader Loulia, Sherbash Mohamed, Elawady Mostafa Ibrahim, Abdalazim Walaa, Howady Faraj, Elewa Hazem
Abstract excerpt
Warfarin is extensively metabolized by cytochrome P450 2C9 (CYP2C9). Concomitant use with the potent CYP2C9 inducer, rifampin, requires close monitoring and dosage adjustments. Although, in theory, warfarin dose increase should overcome this interaction, most reported cases over the last 50 years have not responded even to high warfarin doses, but some have responded to modest doses. To investigate the genetic...
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