Article
CYP3A4 and CYP3A5 Expression is Regulated by CYP3A4*1G in CRISPR/Cas9-Edited HepG2 Cells.
Drug metabolism and disposition: the biological fate of chemicals - 1 Apr 2023
Yang Weihong, Zhao Huan, Dou Yaojie, Wang Pei, Chang Qi, Qiao Xiaomeng, Wang Xiaofei, Xu Chen, Zhang Zhe, Zhang Lirong
Abstract excerpt
Functional CYP3A4*1G (G>A, rs2242480) in cytochrome P450 3A4 (CYP3A4) regulates the drug-metabolizing enzyme CYP3A4 expression. The objective of this study was to investigate whether CYP3A4*1G regulates both basal and rifampicin (RIF)-induced expression and enzyme activity of CYP3A4 and CYP3A5 in gene-edited human HepG2 cells. CYP3A4*1G GG and AA genotype HepG2 cells were established using the clustered regularly...
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