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Article

Variations in prothrombin time-international normalized ratio caused by drug-drug interaction in patients receiving warfarin: A retrospective observational study.

International journal of clinical pharmacology and therapeutics - 1 Apr 2023

Shiraishi Chihiro, Hirai Toshinori, Fujita Satoshi, Dohi Kaoru, Iwamoto Takuya

Abstract excerpt

OBJECTIVES: Drug-drug interactions between warfarin and cytochrome P450 (CYP) 2C9 inhibitors and inducers are well known. Few studies have clarified the clinical impact of CYP2C9 inhibitors and inducers on warfarin therapy. Here, we evaluated the clinical impact of CYP2C9-mediated interactions on the pharmacodynamics of warfarin. MATERIALS AND METHODS: This retrospective observational study enrolled patients who...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 36633369
DOI: 10.5414/CP204306

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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