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Article

Ultra-low-coverage genome-wide association study-insights into gestational age using 17,844 embryo samples with preimplantation genetic testing.

Genome medicine - 14 Feb 2023

Li Shumin, Yan Bin, Li Thomas K T, Lu Jianliang, Gu Yifan, Tan Yueqiu, Gong Fei, Lam Tak-Wah, Xie Pingyuan, Wang Yuexuan, Lin Ge, Luo Ruibang

Abstract excerpt

BACKGROUND: Very low-coverage (0.1 to 1×) whole genome sequencing (WGS) has become a promising and affordable approach to discover genomic variants of human populations for genome-wide association study (GWAS). To support genetic screening using preimplantation genetic testing (PGT) in a large population, the sequencing coverage goes below 0.1× to an ultra-low level. However, the feasibility and effectiveness of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 36788602
DOI: 10.1186/s13073-023-01158-7
PMCID: PMC9926832

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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