Article

Genome-Wide Disease Screening of Early Human Embryos at Base-Pair Resolution

2022-08-08

Abstract excerpt

<title>Abstract</title> <p>Whole-genome sequencing of preimplantation human embryos (PGT-WGS) is not currently performed due to the insufficient quality of amplified DNA from embryo biopsies. Here we present a PGT-WGS approach that takes advantage of the improved genome coverage and uniformity of primary template-directed amplification (PTA) to call almost all early embryo genetic variants accurately and reproduc...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 78e457bc-bbbb-5b84-978a-704ee9188a1d
DOI: 10.21203/rs.3.rs-1883439/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Genome-Wide Disease Screening of Early Human Embryos at Base-Pair ResolutionDOI 10.21203/rs.3.rs-1883439/v1Read

Genome-Wide Disease Screening in Early Human Embryos with Primary Template-Directed AmplificationSemantic proximity Read

Comprehensive preimplantation genetic testing by massively parallel sequencingSemantic proximity Read

Whole-genome risk prediction of common diseases in human preimplantation embryosSemantic proximity Read

First clinical validation of whole genome screening on standard trophectoderm biopsies of preimplantation embryosSemantic proximity Read

The first clinical validation of whole-genome screening on standard trophectoderm biopsies of preimplantation embryosSemantic proximity Read

Identifying risk variants for embryo aneuploidy using ultra-low coverage whole-genome sequencing from preimplantation genetic testingSemantic proximity Read

Concordance of whole-genome amplified embryonic DNA with the subsequently born childSemantic proximity Read

Clinical-grade whole genome sequencing-based haplarithmisis enables all forms of preimplantation genetic testingSemantic proximity Read

Whole genome prediction for preimplantation genetic diagnosisSemantic proximity Read

Genome sequencing of human in vitro fertilisation embryos for pathogenic variation screeningSemantic proximity Read

A comprehensive and universal approach for embryo testing in patients with different genetic disorders.Semantic proximity Read

Embryo genome profiling by single-cell sequencing for preimplantation genetic diagnosis in a β-thalassemia family.Semantic proximity Read