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Article

Protocol for genetic analysis of population-scale ultra-low-depth sequencing data.

STAR protocols - 21 Mar 2025

Zeng Jingyu, Li Linxuan, Lin Ying, Lan Xianmei, Zhang Xinyi, Wang Yingying, Liao Mingzhi, Jin Xin, Zhu Huanhuan

Abstract excerpt

Non-invasive prenatal testing (NIPT) not only enables the detection of chromosomal anomalies in fetuses but also generates vast amounts of ultra-low-depth sequencing data, which can be leveraged for population genomic studies. Here, we present a protocol designed for massive ultra-low-depth sequencing datasets. We detail the steps for data processing, quality control, and genotype imputation, followed by...

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Identifiers

PMID: 39826115
DOI: 10.1016/j.xpro.2024.103579
PMCID: PMC11787503

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