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Article

Preeclampsia risk prediction from prenatal cell-free DNA screening

12 Feb 2025

Abstract excerpt

Preeclampsia is characterized by placental dysfunction and results in significant morbidity, but reliable early prediction remains challenging. We investigated whether clinically obtained prenatal cell-free DNA (cfDNA) screening (PDNAS) using whole-genome sequencing (WGS) data can be leveraged to predict preeclampsia risk early in pregnancy (≤16 weeks). Using 1,854 routinely collected clinical PDNAS samples...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 39939524
DOI: 10.1038/s41591-025-03509-w

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