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GDBIG: A Pioneering Birth Cohort Genomic Platform Facilitating Intergenerational Genetic Research.

Genomics, proteomics & bioinformatics - 28 Oct 2025

Huang Shujia, Wang Chengrui, Huang Mingxi, Lu Jinhua, He Jian-Rong, Lin Shanshan, Liu Siyang, Xia Huimin, Qiu Xiu

Abstract excerpt

High-quality genome databases derived from large-scale, family-based birth cohorts are vital resources for investigating the genetic determinants of early-life traits and the impact of early-life environments on the health of both parents and offspring. Here, we established a genomic platform for the Born in Guangzhou Cohort Study (BIGCS), the Genome Database of BIGCS (GDBIG), which represents the first birth...

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PMID: 40372478
DOI: 10.1093/gpbjnl/qzaf045
PMCID: PMC12944825

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