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Article

Cell Survival Enabled by Leakage of a Labile Metabolic Intermediate.

Molecular biology and evolution - 4 Mar 2023

Medina-Carmona Encarnación, Gutierrez-Rus Luis I, Manssour-Triedo Fadia, Newton Matilda S, Gamiz-Arco Gloria, Mota Antonio J, Reiné Pablo, Cuerva Juan Manuel, Ortega-Muñoz Mariano, Andrés-León Eduardo, Ortega-Roldan Jose Luis, Seelig Burckhard, Ibarra-Molero Beatriz, Sanchez-Ruiz Jose M

Abstract excerpt

Many metabolites are generated in one step of a biochemical pathway and consumed in a subsequent step. Such metabolic intermediates are often reactive molecules which, if allowed to freely diffuse in the intracellular milieu, could lead to undesirable side reactions and even become toxic to the cell. Therefore, metabolic intermediates are often protected as protein-bound species and directly transferred between...

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PMID: 36788592
DOI: 10.1093/molbev/msad032
PMCID: PMC9989741

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