Article
Proline transport and stress tolerance of ammonia-insensitive mutants of the PUT4-encoded proline-specific permease in yeast.
The Journal of general and applied microbiology - 1 Dec 2009
Poole Kate, E Walker Michelle, Warren Tristan, Gardner Jennie, McBryde Colin, de Barros Lopes Miguel, Jiranek Vladimir
Abstract excerpt
The imino amino acid, proline, has roles in both cellular nutrition and response to stress. Proline uptake in Saccharomyces cerevisiae is largely mediated by a high affinity, specific permease, Put4p, and a low affinity general amino acid permease, Gap1p. Both are subject to nitrogen catabolite repression (NCR) and nitrogen catabolite inactivation (NCI). In order for proline to be fully exploited, its transport...
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