Early Triple-Negative Breast Cancers in a Singapore Cohort Exhibit High PIK3CA Mutation Rates Associated With Low PD-L1 Expression.

doi:10.1016/j.modpat.2022.100056

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Article

Early Triple-Negative Breast Cancers in a Singapore Cohort Exhibit High PIK3CA Mutation Rates Associated With Low PD-L1 Expression.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Apr 2023

Yeong Joe, Goh Denise, Tan Tira J, Tan Benedict, Sivaraj Huren, Koh Valerie, Tatt Lim Jeffrey Chun, Joseph Craig Ryan, Ye Jiangfeng, Yong Tay Timothy Kwang, Chan Lau Mai, Chan Jason Yongsheng, Ng Cedric, Iqbal Jabed, Teh Bin Tean, Dent Rebecca Alexandra, Tan Puay Hoon

Abstract excerpt

Mutations in the PI3K pathway, particularly PIK3CA, were reported to be intimately associated with triple-negative breast cancer (TNBC) progression and the development of treatment resistance. We profiled PIK3CA and other genes on 166 early-stage TNBC tumors from Singapore for comparison to publicly available TNBC cohorts. These tumors were profiled transcriptionally using a NanoString panel of immune genes and...

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PMID: 36788078
DOI: 10.1016/j.modpat.2022.100056

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