Article
The molecular landscape of Asian breast cancers reveals clinically relevant population-specific differences.
Nature communications - 22 Dec 2020
Pan Jia-Wern, Zabidi Muhammad Mamduh Ahmad, Ng Pei-Sze, Meng Mei-Yee, Hasan Siti Norhidayu, Sandey Bethan, Sammut Stephen-John, Yip Cheng-Har, Rajadurai Pathmanathan, Rueda Oscar M, Caldas Carlos, Chin Suet-Feung, Teo Soo-Hwang
Abstract excerpt
Molecular profiling of breast cancer has enabled the development of more robust molecular prognostic signatures and therapeutic options for breast cancer patients. However, non-Caucasian populations remain understudied. Here, we present the mutational, transcriptional, and copy number profiles of 560 Malaysian breast tumours and a comparative analysis of breast cancers arising in Asian and Caucasian women....
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