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Early triple negative breast cancers in a Singapore cohort exhibit high PIK3CA mutation rates associated with low PD-L1 expression

2022-08-05

Abstract excerpt

<title>Abstract</title> <p>Mutations in the PI3K pathway, particularly of <italic>PIK3CA</italic>, were reported to be intimately associated with triple negative breast cancer (TNBC) progression and development of treatment resistance. We profiled <italic>PIK3CA</italic> and other genes on 166 early-stage TNBC tumors from Singapore, for comparison to publicly available TNBC cohorts. These tumors were profiled tra...

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Literature Corpus work: 31d6e976-6373-551f-903a-3941f3a82a28
DOI: 10.21203/rs.3.rs-1876811/v1

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