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Pan-cancer analysis on the role of PIK3R1 and PIK3R2 in human tumors

8 Apr 2022

Abstract excerpt

Phosphoinositide-3-Kinase Regulatory Subunit 1 (PIK3R1) is believed to function as a tumor suppressor, while Phosphoinositide-3-Kinase Regulatory Subunit 2 (PIK3R2) as a tumor driver. However, there is no systematic pan-cancer analysis of them. The pan-cancer study comprehensively investigated the gene expression, genetic alteration, DNA methylation, and prognostic significance of PIK3R1 and PIK3R2 in 33...

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PMID: 35395865
DOI: 10.1038/s41598-022-09889-0

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