Article
Subpopulation Heterogeneity of NK Cells during the Genetic Modification for Subsequent Use in Targeted Therapy.
Doklady. Biochemistry and biophysics - 1 Dec 2022
Streltsova M A, Boyko A A, Ustiuzhanina M O, Palamarchuk A I, Alekseeva N A, Velichinskii R A, Vavilova J D, Grechikhina M V, Sapozhnikov A M, Deev S M, Kovalenko E I
Abstract excerpt
Obtaining genetically engineered NK cells is a developing area of immunotherapy. In this work, we analyzed the subset heterogeneity of NK cells subjected to retroviral transduction, taking into account the content of adaptive NK cell progenitors. It was shown that subsets KIR2DL2/DL3+, as well as CD57-KIR2DL2/DL3+NKG2C+, can be modified with greater efficiency than the corresponding subsets that do not carry the...
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