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Diagnostic reassessment in myeloproliferative neoplasms: the value of functional iron parameters and JAK2 allelic burden.

Annals of hematology - 24 Jan 2026

González-Resina Rita, España-Fernández de Valderrama Sara, Montañés Ángeles, Recasens Valle, Caballero Gonzalo

Abstract excerpt

Polycythemia vera (PV) and essential thrombocythemia (ET) are chronic myeloproliferative neoplasms (MPNs), often associated with mutations in JAK2, CALR, and MPL. Differentiating PV from ET can be challenging in borderline cases, particularly when hemoglobin (Hb), hematocrit (Hct) and erythropoietin (EPO) values are inconclusive. Functional iron parameters and JAK2 variant allele frequency (VAF) may provide...

Topics

Humans
Janus Kinase 2
Female
Polycythemia Vera
Iron
Retrospective Studies
Aged
Middle Aged
Male
Alleles
Ferritins
Thrombocythemia, Essential

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Erythropoietin

Gene Frequency

Adult

Mutation

Aged, 80 and over

Myeloproliferative Disorders

Source

Open in PubMed Open full text

Identifiers

PMID: 41577837
DOI: 10.1007/s00277-026-06774-y
PMCID: PMC12830395

Genes

JAK2
EPO
CALR
MPL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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