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Article

Diagnostic reassessment in myeloproliferative neoplasms: the value of functional iron parameters and JAK2 allelic burden.

Annals of hematology - 24 Jan 2026

González-Resina Rita, España-Fernández de Valderrama Sara, Montañés Ángeles, Recasens Valle, Caballero Gonzalo

Abstract excerpt

Polycythemia vera (PV) and essential thrombocythemia (ET) are chronic myeloproliferative neoplasms (MPNs), often associated with mutations in JAK2, CALR, and MPL. Differentiating PV from ET can be challenging in borderline cases, particularly when hemoglobin (Hb), hematocrit (Hct) and erythropoietin (EPO) values are inconclusive. Functional iron parameters and JAK2 variant allele frequency (VAF) may provide...

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Source

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Identifiers

PMID: 41577837
DOI: 10.1007/s00277-026-06774-y
PMCID: PMC12830395

Genes

JAK2
EPO
CALR
MPL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 19 Oct 2026.

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