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Cerebrospinal Fluid Liquid Biopsy Enables Targeted Therapy Without Tissue Diagnosis in Pediatric Low-Grade Gliomas With BRAF V600E Mutation.

Pediatric blood & cancer - 1 Mar 2026

Sultan Hannah, Faury Damien, Weil Alexander G, Westwick Harrison J, Jabado Nada, Perreault Sébastien

Abstract excerpt

We present two pediatric cases of pediatric low-grade gliomas (PLGG) with BRAF V600E mutations diagnosed and monitored using cerebrospinal fluid (CSF) liquid biopsy analyzed via digital droplet PCR (ddPCR), without tissue biopsy. Both patients were treated with dabrafenib and trametinib and monitored through clinical assessments, magnetic resonance imaging (MRI), and repeat CSF analyses. Both patients showed...

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PMID: 41502340
DOI: 10.1002/1545-5017.70093

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BRAF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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