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Article

Impaired mitochondrial degradation by autophagy in the skeletal muscle of the aged female interleukin 10 null mouse.

Experimental gerontology - 1 Jan 2016

Ko Fred, Abadir Peter, Marx Ruth, Westbrook Reyhan, Cooke Carol, Yang Huanle, Walston Jeremy

Abstract excerpt

Mitochondrial dysfunction, chronic inflammation and muscle aging are closely linked. Mitochondrial clearance is a process to dampen inflammation and is a critical pre-requisite to mitobiogenesis. The combined effect of aging and chronic inflammation on mitochondrial degradation by autophagy is understudied. In interleukin 10 null mouse (IL-10(tm/tm)), a rodent model of chronic inflammation, we studied the effects...

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Identifiers

PMID: 26596403
DOI: 10.1016/j.exger.2015.11.010
PMCID: PMC4725733

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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