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Article

Treatment outcome of IDH1/2 wildtype CNS WHO grade 4 glioma histologically diagnosed as WHO grade II or III astrocytomas.

Journal of neuro-oncology - 1 Mar 2024

Keric Naureen, Krenzlin Harald, Kalasauskas Darius, Freyschlag Christian F, Schnell Oliver, Misch Martin, von der Brelie Christian, Gempt Jens, Krigers Aleksandrs, Wagner Arthur, Lange Felipa, Mielke Dorothee, Sommer Clemens, Brockmann Marc A, Meyer Bernhard, Rohde Veit, Vajkoczy Peter, Beck Jürgen, Thomé Claudius, Ringel Florian

Abstract excerpt

BACKGROUND: Isocitrate dehydrogenase (IDH)1/2 wildtype (wt) astrocytomas formerly classified as WHO grade II or III have significantly shorter PFS and OS than IDH mutated WHO grade 2 and 3 gliomas leading to a classification as CNS WHO grade 4. It is the aim of this study to evaluate differences in the treatment-related clinical course of these tumors as they are largely unknown. METHODS: Patients undergoing...

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Identifiers

PMID: 38326661
DOI: 10.1007/s11060-024-04585-7
PMCID: PMC10978634

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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