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Article

Translational significance of CDKN2A/B homozygous deletion in isocitrate dehydrogenase-mutant astrocytoma.

Neuro-oncology - 5 Jan 2023

Fortin Ensign Shannon P, Jenkins Robert B, Giannini Caterina, Sarkaria Jann N, Galanis Evanthia, Kizilbash Sani H

Abstract excerpt

Isocitrate dehydrogenase (IDH) 1 or 2 mutations confer a favorable prognosis compared to IDH-wildtype in astrocytoma, frequently denoting a lower grade malignancy. However, recent molecular profiling has identified specific aggressive tumor subgroups with clear clinical prognostic implications that are independent of histologic grading. The homozygous deletion of CDKN2A/B is the strongest implicated independent...

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Identifiers

PMID: 35973817
DOI: 10.1093/neuonc/noac205
PMCID: PMC9825307

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Translational significance of CDKN2A/B homozygous deletion in isocitrate dehydrogenase-mutant astrocytoma.PMID 35973817Read ↗

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