Article
CD206+ macrophages transventricularly infiltrate the early embryonic cerebral wall to differentiate into microglia.
Cell reports - 28 Feb 2023
Hattori Yuki, Kato Daisuke, Murayama Futoshi, Koike Sota, Asai Hisa, Yamasaki Ayato, Naito Yu, Kawaguchi Ayano, Konishi Hiroyuki, Prinz Marco, Masuda Takahiro, Wake Hiroaki, Miyata Takaki
Abstract excerpt
The relationships between tissue-resident microglia and early macrophages, especially their lineage segregation outside the yolk sac, have been recently explored, providing a model in which a conversion from macrophages seeds microglia during brain development. However, spatiotemporal evidence to support such microglial seeding in situ and to explain how it occurs has not been obtained. By cell tracking via slice...
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