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Pyrosequencing Assay for BRCA1 Methylation Analysis: Results from a Cross-Validation Study.

The Journal of molecular diagnostics : JMD - 1 Apr 2023

Sahnane Nora, Rivera Daniela, Libera Laura, Carnevali Ileana, Banelli Barbara, Facchi Sofia, Gismondi Viviana, Paudice Michele, Cirmena Gabriella, Vellone Valerio G, Sessa Fausto, Varesco Liliana, Tibiletti Maria G

Abstract excerpt

Epithelial ovarian cancers (EOCs) harboring germline or somatic pathogenic variants in BRCA1 and BRCA2 genes show sensitivity to poly(ADP-ribose) polymerase inhibition. It has been suggested that BRCA1 promoter methylation is perhaps a better determinant of therapy response, because of its intrinsic dynamic feature, with respect to genomic scars or gene mutation. Conflicting evidence was reported so far, and the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36739964
DOI: 10.1016/j.jmoldx.2023.01.003

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