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Article

Full-exon pyrosequencing screening of BRCA germline mutations in Mexican women with inherited breast and ovarian cancer.

PloS one - 1 Jan 2012

Vaca-Paniagua Felipe, Alvarez-Gomez Rosa María, Fragoso-Ontiveros Verónica, Vidal-Millan Silvia, Herrera Luis Alonso, Cantú David, Bargallo-Rocha Enrique, Mohar Alejandro, López-Camarillo César, Pérez-Plasencia Carlos

Abstract excerpt

Hereditary breast cancer comprises 10% of all breast cancers. The most prevalent genes causing this pathology are BRCA1 and BRCA2 (breast cancer early onset 1 and 2), which also predispose to other cancers. Despite the outstanding relevance of genetic screening of BRCA deleterious variants in patients with a history of familial cancer, this practice is not common in Latin American public institutions. In this...

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PMID: 22655046
DOI: 10.1371/journal.pone.0037432
PMCID: PMC3360054

Genes

BRCA1
BRCA2

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